人甲状腺旁素1型受体的结构特征

林克江 已出版文章查询
林克江
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1 朱冬吉 已出版文章查询
朱冬吉
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1 冷勇敢 已出版文章查询
冷勇敢
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1 尤启冬 已出版文章查询
尤启冬
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1中国药科大学药物化学教研室,南京210009


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人甲状腺旁素1型受体(PTH1R)是骨形成相关的B类G蛋白偶联受体,其底物甲状腺旁腺素(PTH)及类似物具有抗骨质疏松作用,由于此类受体的三维结构难以进行实验测定,本文采用同源模建的方法,完整构建了胞外区、跨膜区及其它相关区域,并通过对接研究,阐明复合物的氢键、疏水性相互作用及其与底物的相互作用关系和关键位点.为进一步设计和发展此类药物提供理论依据.

[1] Potts,J.T;Gardella,T .[J].J Annals of the New York Academy of Sciences,2007,1117:196.

[2] Potts JT .Parathyroid hormone: past and present.[J].The Journal of Endocrinology: The Journal of the Society for Endocrinology,2005(3):311-325.

[3] Murray TM;Rao LG;Divieti P;Bringhurst FR .Parathyroid hormone secretion and action: evidence for discrete receptors for the carboxyl-terminal region and related biological actions of carboxyl- terminal ligands.[J].Endocrine Reviews,2005(1):78-113.

[4] Gardella TJ;Juppner H .Molecular properties of the PTH/PTHrP receptor.[J].Trends in Endocrinology and Metabolism: TEM,2001(5):210-217.

[5] Juppner,H;Abou-Samra,A.B;Freeman,M;Kong,X.F Schipani,E Richards,J Kolakowski,L.F.,Jr Hock,J Potts,J.T.,Jr Kronenberg,H.M .[J].Science,1991,254:1024.

[6] Pioszak AA;Harikumar KG;Parker NR;Miller LJ;Xu HE .Dimeric arrangement of the parathyroid hormone receptor and a structural mechanism for ligand-induced dissociation.[J].The Journal of biological chemistry,2010(16):12435-12444.

[7] Pioszak,A.A;Xu,H.E .[J].Proceedings of the National Academy of Sciences(USA),2008,105:5034.

[8] Jin L;Briggs SL;Chandrasekhar S;Chirgadze NY;Clawson DK;Schevitz RW;Smiley DL;Tashjian AH;Zhang F .Crystal structure of human parathyroid hormone 1-34 at 0.9-A resolution.[J].The Journal of biological chemistry,2000(35):27238-27244.

[9] Rolz C;Pellegrini M;Mierke DF .Molecular characterization of the receptor-ligand complex for parathyroid hormone.[J].Biochemistry,1999(20):6397-6405.

[10] Discovery Studio,2.5[M].Accelrys Software Inc,San Diego,US,2010

[11] Pellegrini,M;Bisello,A;Rosanblatt,M;Chorev,M Mierke,D.F .[J].Bochemistry,1998,37:12737.

[12] Cherezov V;Rosenbaum DM;Hanson MA;Rasmussen SG;Thian FS;Kobilka TS;Choi HJ;Kuhn P;Weis WI;Kobilka BK;Stevens RC .High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.[J].Science,2007(5854):1258-1265.

[13] Kerfeld CA.;Interrante R.;Merchant S.;Yeates TO.;Anwar HP. .THE STRUCTURE OF CHLOROPLAST CYTOCHROME C6 AT 1.9 ANGSTROM RESOLUTION - EVIDENCE FOR FUNCTIONAL OLIGOMERIZATION[J].Journal of Molecular Biology,1995(5):627-647.

[14] Thompson,J.D;Higgins,D.G;Gibson,T .[J].Journal of Nucleic Acids Research,1994,22:4673.

[15] Spassov,V;Yan,L;Szalma,S .[J].Journal of Physical Chemistry B,2002,106:8726.

[16] Im,W;Lee,M.S;Brooks,C.L .[J].Journal of Computational Chemistry,2003,24:1691.

[17] Luthy,R;Bowie,J.U;Eisenberg,D .[J].Nature,1992,356:83.

[18] Lovell SC;Davis IW;Arendall-WB 3rd;de-Bakker PI;Word JM;Prisant MG;Richardson JS;Richardson DC .Structure validation by Calpha geometry: phi,psi and Cbeta deviation.[J].Proteins: Structure, Function, and Genetics,2003(3):437-450.

[19] Adams,A.E;Bisello,A;Chorev,M;Rosenblatt,M Suva,L .[J].Journal of Molecular Endocrinology,1998,12:1673.

[20] Fletcher,R;Powell,M.J.D .[J].Computer Journal,1963,6:163.

[21] Grippo L.;Lucidi S. .A GLOBALLY CONVERGENT VERSION OF THE POLAK-RIBIERE CONJUGATE GRADIENT METHOD[J].Mathematical Programming,1997(3):375-391.

[22] MOE,2009[M].Chemical Computing Group:Montreal,Canada,2009

[23] Clark AM;Labute P .2D depiction of protein - Ligand complexes[J].Journal of chemical information and modeling,2007(5):1933-1944.

[24] Greenbarg,Z;Bisello,A;Mierke,D.F;Rosenblatt,M Chorev,M .[J].Bochemistry,2000,39:8142.

[25] Sali,A .[J].Molecular Medicine Today,1995,1:270.

[26] Dean T;Khatri A;Potetinova Z;Willick GE;Gardella TJ .Role of amino acid side chains in region 17-31 of parathyroid hormone (PTH) in binding to the PTH receptor.[J].The Journal of biological chemistry,2006(43):32485-32495.

[27] Barbier,J.R;Gardella,T.J;Dean,T;MacLean,S Potetinova,Z Whitfield,J.F Willick,G.E .[J].Journal of Biological Chemistry,2005,280:23771.

[28] Mierke DF;Maretto S;Schievano E;DeLuca D;Bisello A;Mammi S;Rosenblatt M;Peggion E;Chorev M .Conformational studies of mono- and bicyclic parathyroid hormone-related protein-derived agonists[J].Biochemistry,1997(34):10372-10383.

[29] Caporale A;Biondi B;Schievano E .Structure-function relationship studies of PTH(1-11) analogues containing D-amino acids.[J].European Journal of Pharmacology,2009(1/3):1-7.

[30] Pioszak,A.A;Parker,N.R;Gardella,T.J;Xu,H.E .[J].Journal of Biological Chemistry,2009,284:28382.

[31] Piserchio,A;Bisello,A;Rosenblatt,M;Chorev,M Mierke,D.F .[J].Bochemistry,2000,39:8153.

[32] Hoare SR .Mechanisms of peptide and nonpeptide ligand binding to Class B G-protein-coupled receptors.[J].Drug discovery today,2005(6):417-427.

[33] Mierke DF;Mao L;Pellegrini M;Piserchio A;Plati J;Tsomaia N .Structural characterization of the parathyroid hormone receptor domains determinant for ligand binding.[J].Biochemical Society Transactions,2007(Pt.4):721-723.

[34] Rolz C;Mierke DF .Characterization of the molecular motions of constitutively active G protein-coupled receptors for parathyroid hormone.[J].Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena,2001(2/3):119-128.

[35] Barbier,J.R;MacLean,S;Whitfield,J.F;Morley,P Willick,G.E .[J].Bochemistry,2001,40:8955.

[36] Luck,M.D;Carter,P.H;Gardella,T .[J].Journal of Molecular Endocrinology,1999,13:670.

[37] Gardella,T.J;Juppner,H;Wilson,A.K;Keutmann,H.T Abou-Samra,A.B Segre,G.V Bringhurst,F.R Potts,J.T.,Jr Nussbaum,S.R Kronenberg,H.M .[J].Endocrinology,1994,135:1186.

[38] Bisello A;Adams AE;Mierke DF;Pellegrini M;Rosenblatt M;Suva LJ;Chorev M .Parathyroid hormone-receptor interactions identified directly by photocross-linking and molecular modeling studies.[J].The Journal of biological chemistry,1998(35):22498-22505.

[39] Monticelli L;Mammi S;Mierke DF .Molecular characterization of a ligand-tethered parathyroid hormone receptor.[J].Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena,2002(2):165-172.

[40] Gensure,R.C;Shimizu,N;Tsang,J;Gardella,T .[J].Journal of Molecular Endocrinology,2003,17:2647.



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